The draw for the Copa del Rey quarter-final was conducted on Monday.
Barcelona and Real Madrid have again avoided each other and remain on track to meet in the latter stages of the competition.
Both teams have been given away ties in the last eight. Barça travel, while Los Blancos have been drawn against Leganés.
The other quarter-finals ties will see Atlético Madrid host Getafe and Real Sociedad take on Osasuna, who knocked out holders Athletic Club in the last round.
All four games are scheduled to be played the week commencing February 3, with the winners progressing to a two-legged semi-final.
That could mean two more Clásicos this season if both Barça and Madrid progress and draw each other in the last four.
There also remains the possibility of a Madrid derby in the latter stage of the competition if both Real and Atlético continue to progress.
Copa del Rey quarterfinals:
Valencia vs. Barcelona Leganés vs. Real Madrid Atlético Madrid vs. Getafe Real Sociedad vs. Osasuna
