Arsenal manager, Mikel Arteta, has made six changes after defeat, midweek to Villarreal.
Jurrien Timber, Gabriel and Riccardo Calafiori will replace Ben White, Jakub Kiwior and Myles Lewis-Skelly respectively.
There are more changes in midfield with the combination of Martin Zubimendi, Declan Rice and Martin Odegaard starting in place of Christian Norgaard, Mikel Merino and Ethan Nwaneri.
Youngster Max Dowman is not in the squad as he has been given a rest.
Kai Havertz, meanwhile, returns to the bench but there’s no place for Leandro Trossard.
Arsenal Team to play Athletic Club include Raya; Timber, Saliba, Gabriel, Calafiori; Odegaard, Zubimendi, Rice; Saka, Gyokeres, Martinelli.
Athletic Team to face Arsenal: Unai Simon, Areso, Vivian, Lekue, Yuri, Galarreta, Jauregizar, Inaki Williams, Unai Gomez, Nico Williams, Berenguer.
